HER2-Specific Pseudomonas Exotoxin A PE25 Based Fusions: Influence of Targeting Domain on Target Binding, Toxicity, and In Vivo Biodistribution

• Main Authors: Haozhong Ding (Author), Mohamed Altai (Author), Wen Yin (Author), Sarah Lindbo (Author), Hao Liu (Author), Javad Garousi (Author), Tianqi Xu (Author), Anna Orlova (Author), Vladimir Tolmachev (Author), Sophia Hober (Author), Torbjörn Gräslund (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The human epidermal growth factor receptor 2 (HER2) is a clinically validated target for cancer therapy, and targeted therapies are often used in regimens for patients with a high HER2 expression level. Despite the success of current drugs, a number of patients succumb to their disease, which motiva...