Night work and breast cancer estrogen receptor status - results from the German GENICA study

• Main Authors: Sylvia Rabstein (Author), Volker Harth (Author), Beate Pesch (Author), Dirk Pallapies (Author), Anne Lotz (Author), Christina Justenhoven (Author), Christian Baisch (Author), Markus Schiffermann (Author), Susanne Haas (Author), Hans-Peter Fischer (Author), Evelyn Heinze (Author), Christiane Pierl (Author), Hiltrud Brauch (Author), Ute Hamann (Author), Yon Ko (Author), Thomas Brüning (Author)
• Format: Book
• Published: Nordic Association of Occupational Safety and Health (NOROSH), 2013-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

OBJECTIVES: The potential mechanisms that link night-shift work with breast cancer have been extensively discussed. Exposure to light at night (LAN) depletes melatonin that has oncostatic and anti-estrogenic properties and may lead to a modified expression of estrogen receptor (ER) α. Here, we explo...