Clinical and pathological characterization of Central Nervous System cryptococcosis in an experimental mouse model of stereotaxic intracerebral infection.

• Main Authors: Mohamed F Hamed (Author), Vanessa Enriquez (Author), Melissa E Munzen (Author), Claudia L Charles-Niño (Author), Mircea Radu Mihu (Author), Habibeh Khoshbouei (Author), Karina Alviña (Author), Luis R Martinez (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infection of the Central Nervous System (CNS) by the encapsulated fungus Cryptococcus neoformans can lead to high mortality meningitis, most commonly in immunocompromised patients. While the mechanisms by which the fungus crosses the blood-brain barrier to initiate infection in the CNS are well reco...