The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?

• Main Authors: Jean-Louis Charli (Author), Adair Rodríguez-Rodríguez (Author), Karina Hernández-Ortega (Author), Antonieta Cote-Vélez (Author), Rosa María Uribe (Author), Lorraine Jaimes-Hoy (Author), Patricia Joseph-Bravo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thyrotropin releasing hormone (TRH: Glp-His-Pro-NH2) is a peptide mainly produced by brain neurons. In mammals, hypophysiotropic TRH neurons of the paraventricular nucleus of the hypothalamus integrate metabolic information and drive the secretion of thyrotropin from the anterior pituitary, and thus...