Pharmacogenetics-based population pharmacokinetic analysis and dose optimization of valproic acid in Chinese southern children with epilepsy: Effect of ABCB1 gene polymorphism

• Main Authors: Xianhuan Shen (Author), Xinyi Chen (Author), Jieluan Lu (Author), Qing Chen (Author), Wenzhou Li (Author), Jiahao Zhu (Author), Yaodong He (Author), Huijuan Guo (Author), Chenshu Xu (Author), Xiaomei Fan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The aim of this study was to establish a population pharmacokinetic (PPK) model of valproic acid (VPA) in pediatric patients with epilepsy in southern China, and provide guidance for individualized medication of VPA therapy.Methods: A total of 376 VPA steady-state trough concentrations we...