Antifibrotic Effect of a Novel Selective 11β-HSD2 Inhibitor (WZ51) in a rat Model of Myocardial Fibrosis

• Autori principali: Fei Zhuang (Autore), Qin Ge (Autore), Jianchang Qian (Autore), Zhe Wang (Autore), Yaoyao Dong (Autore), Mengchun Chen (Autore), Xiaodan Zhang (Autore), Wei Sun (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Myocardial fibrosis (MF) is one of the leading causes of end-stage heart disease. Many studies have confirmed that inflammation caused by aldosterone may play an important role in the process of MF. A selective 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) enzyme inhibitor can reduce the inacti...