The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication

• Main Authors: Elisa Bianconi (Author), Anna Gidari (Author), Maria Souma (Author), Samuele Sabbatini (Author), Deborah Grifagni (Author), Carlo Bigiotti (Author), Elisabetta Schiaroli (Author), Lucia Comez (Author), Alessandro Paciaroni (Author), Francesca Cantini (Author), Daniela Francisci (Author), Antonio Macchiarulo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Non-structural protein 5 (Nsp5) is a cysteine protease that plays a key role in SARS-CoV-2 replication, suppressing host protein synthesis and promoting immune evasion. The investigation of natural products as a potential strategy for Nsp5 inhibition is gaining attention as a means of developing ant...