Ac-EAZY! Towards GMP-Compliant Module Syntheses of ²²⁵Ac-Labeled Peptides for Clinical Application

• Main Authors: Marc Pretze (Author), Falk Kunkel (Author), Roswitha Runge (Author), Robert Freudenberg (Author), Anja Braune (Author), Holger Hartmann (Author), Uwe Schwarz (Author), Claudia Brogsitter (Author), Jörg Kotzerke (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The application of ²²⁵Ac (half-life T_1/2 = 9.92 d) dramatically reduces the activity used for peptide receptor radionuclide therapy by a factor of 1000 in comparison to ⁹⁰Y, ¹⁷⁷Lu or ¹⁸⁸...