A competitive ligand-binding assay for the detection of neutralizing antibodies against dostarlimab (TSR-042)

Abstract Dostarlimab is a humanized anti-PD-1 monoclonal antibody. Dostarlimab (JEMPERLI; TSR-042) was recently approved in the USA and in the EU. The presence of neutralizing antibodies (NAbs) is a cause for concern because they block the therapeutic function of the antibody and reduce drug efficac...

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Main Authors: Xiaolong Tom Zhang (Author), Hong Chen (Author), Weiping Shao (Author), Zhongping John Lin (Author), Murad Melhem (Author), Sharon Lu (Author)
Format: Book
Published: SpringerOpen, 2021-11-01T00:00:00Z.
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