Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification

• Main Authors: Sabine Schuster (Author), Beáta Biri-Kovács (Author), Bálint Szeder (Author), László Buday (Author), János Gardi (Author), Zsuzsanna Szabó (Author), Gábor Halmos (Author), Gábor Mező (Author)
• Format: Book
• Published: MDPI AG, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Receptors for gonadotropin releasing hormone (GnRH) are highly expressed in various human cancers including breast, ovarian, endometrial, prostate and colorectal cancer. Ligands like human GnRH-I or the sea lamprey analogue GnRH-III represent a promising approach for the development of efficient dru...