Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling

• Autori principali: Gongsheng Yuan (Autore), Shu-ting Yang (Autore), Shuying Yang (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2023-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Synovial fibroblasts are the active and aggressive drivers in the progression of arthritis, but the cellular and molecular mechanisms remain unknown. Here, our results showed that regulator of G protein signaling 12 (RGS12) maintained ciliogenesis in synovial fibroblasts, which is critical for the d...