Derivation of a Human In Vivo Benchmark Dose for Bisphenol A from ToxCast In Vitro Concentration Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation

• Auteurs principaux: George Loizou (Auteur), Kevin McNally (Auteur), Alicia Paini (Auteur), Alex Hogg (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

A computational workflow which integrates physiologically based kinetic (PBK) modelling; global sensitivity analysis (GSA), Approximate Bayesian Computation (ABC), Markov Chain Monte Carlo (MCMC) simulation and the Virtual Cell Based Assay (VCBA) for the estimation of the active, free in vitro conce...