3,4-Difluorobenzocurcumin Inhibits Vegfc-Vegfr3-Erk Signalling to Block Developmental Lymphangiogenesis in Zebrafish

• Main Authors: Kazuhide S. Okuda (Author), Mei Fong Ng (Author), Nur Faizah Ruslan (Author), Neil I. Bower (Author), Dedrick Soon Seng Song (Author), Huijun Chen (Author), Sungmin Baek (Author), Philip S. Crosier (Author), Katarzyna Koltowska (Author), Jonathan W. Astin (Author), Pei Jean Tan (Author), Benjamin M. Hogan (Author), Vyomesh Patel (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lymphangiogenesis, the formation of new lymphatic vessels from pre-existing vasculature, plays critical roles in disease, including in cancer metastasis and chronic inflammation. Preclinical and recent clinical studies have now demonstrated therapeutic utility for several anti-lymphangiogenic agents...