Mitochondrial Succinate Metabolism and Reactive Oxygen Species Are Important but Not Essential for Eliciting Carotid Body and Ventilatory Responses to Hypoxia in the Rat

• Main Authors: Agnieszka Swiderska (Author), Andrew M. Coney (Author), Abdulaziz A. Alzahrani (Author), Hayyaf S. Aldossary (Author), Nikolaos Batis (Author), Clare J. Ray (Author), Prem Kumar (Author), Andrew P. Holmes (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Reflex increases in breathing in response to acute hypoxia are dependent on activation of the carotid body (CB)-A specialised peripheral chemoreceptor. Central to CB O₂-sensing is their unique mitochondria but the link between mitochondrial inhibition and cellular stimulation...