Adenine and benzimidazole-based mimics of REP-3123 as antibacterial agents against Clostridium difficile and Bacillus anthracis: Design, synthesis and biological evaluation

• Auteurs principaux: Ahmed G. Eissa (Auteur), James A. Blaxland (Auteur), Rhodri O. Williams (Auteur), Kamel A. Metwally (Auteur), Sobhy M. El-Adl (Auteur), El-Sayed M. Lashine (Auteur), Leslie W.J. Baillie (Auteur), Claire Simons (Auteur)
• Format: Livre
• Publié: Faculty of Pharmacy, Cairo University, 2016-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

As part of our ongoing research efforts to develop new antibacterial agents acting on novel molecular targets, a series of twenty-two adenine and benzimidazole-based mimics of the lead compound REP-3123 was designed to target methionyl-tRNA synthetase of Clostridium difficile and Bacillus anthracis...