2-NPPA Mitigates Osteoclastogenesis via Reducing TRAF6-Mediated c-fos Expression

• Main Authors: Zhihao Chen (Author), Mina Ding (Author), Eunjin Cho (Author), Jihyoun Seong (Author), Sunwoo Lee (Author), Tae-Hoon Lee (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive bone resorption leads to bone destruction in pathological bone diseases. Osteoporosis, which occurs when osteoclast-mediated bone resorption exceeds osteoblast-mediated bone synthesis, is regarded a global health challenge. Therefore, it is of great importance to identify agents that can r...