The deuterated pyrazoloquinolinone targeting α6 subunit-containing GABAA receptor as novel candidate for inhibition of trigeminovascular system activation: implication for migraine therapy

• Principais autores: Pi-Chuan Fan (Autor), Lih-Chu Chiou (Autor), Tzu-Hsuan Lai (Autor), Dishary Sharmin (Autor), James Cook (Autor), Ming Tatt Lee (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

IntroductionThe α6 subunit-containing GABAA receptors (α6GABAARs) are highly expressed in the trigeminal ganglia (TG), the sensory hub of the trigeminovascular system (TGVS). Hypo-GABAergic transmission in the TG was reported to contribute to migraine-related behavioral and histopathological phenoty...