Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes.

• Main Authors: Ulrich F Prodjinotho (Author), Charlotte von Horn (Author), Alex Y Debrah (Author), Linda Batsa Debrah (Author), Anna Albers (Author), Laura E Layland (Author), Achim Hoerauf (Author), Tomabu Adjobimey (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Helminth parasites are known to be efficient modulators of their host's immune system. To guarantee their own survival, they induce alongside the classical Th2 a strong regulatory response with high levels of anti-inflammatory cytokines and elevated plasma levels of IgG4. This particular antibo...