Reactivation of cocaine contextual memory engages mechanistic target of rapamycin/S6 kinase 1 signaling

• Main Authors: Xiangdang Shi (Author), Eva von Weltin (Author), Emma Fitzsimmons (Author), Chau Do (Author), Carolina Caban Rivera (Author), Chongguang Chen (Author), Lee-Yu (Author), Ellen M. Unterwald (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling pathway consisting of Akt, glycogen synthase kinase-3β (GSK3β), and mTORC1. The present s...