Efficacy of Cathelicidin LL-37 in an MRSA Wound Infection Mouse Model

• Main Authors: Oriana Simonetti (Author), Oscar Cirioni (Author), Gaia Goteri (Author), Guendalina Lucarini (Author), Elżbieta Kamysz (Author), Wojciech Kamysz (Author), Fiorenza Orlando (Author), Giulio Rizzetto (Author), Elisa Molinelli (Author), Gianluca Morroni (Author), Roberto Ghiselli (Author), Mauro Provinciali (Author), Andrea Giacometti (Author), Annamaria Offidani (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: LL-37 is the only human antimicrobial peptide that belongs to the cathelicidins. The aim of the study was to evaluate the efficacy of LL-37 in the management of MRSA-infected surgical wounds in mice. Methods: A wound on the back of adult male BALB/c mice was made and inoculated with <...