Key Role of STAT4 Deficiency in the Hematopoietic Compartment in Insulin Resistance and Adipose Tissue Inflammation

• Main Authors: Anca D. Dobrian (Author), Kaiwen Ma (Author), Lindsey M. Glenn (Author), Margaret A. Hatcher (Author), Bronson A. Haynes (Author), Eric J. Lehrer (Author), Mark H. Kaplan (Author), Jerry L. Nadler (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visceral adipose tissue (AT) inflammation is linked to the complications of obesity, including insulin resistance (IR) and type 2 diabetes. Recent data from our lab showed that germline deficiency in STAT4 reduces inflammation and improves IR in obese mice. The objective of this study was to determi...