Heart-Derived Stem Cells in Miniature Swine with Coronary Microembolization: Novel Ischemic Cardiomyopathy Model to Assess the Efficacy of Cell-Based Therapy

A major problem in translating stem cell therapeutics is the difficulty of producing stable, long-term severe left ventricular (LV) dysfunction in a large animal model. For that purpose, extensive infarction was created in sinclair miniswine by injecting microspheres (1.5 × 106 microspheres, 45 μm d...

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Main Authors: Gen Suzuki (Author), Rebeccah F. Young (Author), Merced M. Leiker (Author), Takayuki Suzuki (Author)
Formato: Livro
Publicado em: Hindawi Limited, 2016-01-01T00:00:00Z.
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