Clioquinol Increases the Expression of VGF, a Neuropeptide Precursor, Through Induction of c-Fos Expression

• Main Authors: Masato Katsuyama (Author), Masakazu Ibi (Author), Misaki Matsumoto (Author), Kazumi Iwata (Author), Yoichi Ohshima (Author), Chihiro Yabe-Nishimura (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clioquinol was used extensively in the mid-1900s as an amebicide to treat indigestion and diarrhea. It was eventually withdrawn from the market because it was linked to subacute myelo-optic neuropathy (SMON) in Japan. However, the pathogenesis of SMON has not yet been elucidated in detail. As report...