Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models

• Main Authors: Viviane M. Andrade (Author), Igor Maricic (Author), Richa Kalia (Author), Lauren Jachimowicz (Author), Olivia Bedoya (Author), Daniel W. Kulp (Author), Laurent Humeau (Author), Trevor R. F. Smith (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTNucleic acid vaccines are designed based on genetic sequences (DNA or mRNA) of a target antigen to be expressed in vivo to drive a host immune response. In response to the COVID-19 pandemic, mRNA and DNA vaccines based on the SARS-CoV-2 Spike antigen were developed. Surprisingly, head-to-hea...