Dexamethasone changes the pharmacokinetics of amitriptyline and reduces its accumulation in rat brain: The roles of P-gp and cyp3a2

• Main Authors: Jing Wen (Author), Yuan Shen (Author), Min Zhang (Author), Chao Wang (Author), Yalan Xiang (Author), Hualin Cai (Author), Pingfei Fang (Author), Huande Li (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The wide spread use of central nervous system (CNS) drugs has caused thousands of deaths in clinical practice while there are few antidotes or effective treatments to decrease their accumulation in CNS. In this study, we used amitriptyline (AMI) and dexamethasone (DEX) as the corresponding poisoning...