Development and Validation of a UHPLC-MS/MS Method for Quantitation of Almonertinib in Rat Plasma: Application to an in vivo Interaction Study Between Paxlovid and Almonertinib

• Main Authors: Peng-fei Tang (Author), Su-su Bao (Author), Nan-yong Gao (Author), Chuan-feng Shao (Author), Wei-fei Xie (Author), Xue-meng Wu (Author), Le-ping Zhao (Author), Zhong-xiang Xiao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Almonertinib was approved for the first-line treatment of advanced NSCLC patients with EGFR-TKI-sensitive genetic mutations by National Medical Products Administration (NMPA) in 2021.The purpose of this study was to establish and validate a fast, accurate, stable and facile ultra-performance liquid...