AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome

• Main Authors: Aoife Campbell (Author), Gareth Morris (Author), Albert Sanfeliu (Author), Joana Augusto (Author), Elena Langa (Author), Jaideep C. Kesavan (Author), Ngoc T. Nguyen (Author), Ronan M. Conroy (Author), Jesper Worm (Author), Lukasz Kielpinski (Author), Mads Aaboe Jensen (Author), Meghan T. Miller (Author), Thomas Kremer (Author), Cristina R. Reschke (Author), David C. Henshall (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angelman syndrome (AS) is a severe neurodevelopmental disorder featuring ataxia, cognitive impairment, and drug-resistant epilepsy. AS is caused by mutations or deletion of the maternal copy of the paternally imprinted UBE3A gene, with current precision therapy approaches focusing on re-expression o...