LLDT-8 protects against cerebral ischemia/reperfusion injury by suppressing post-stroke inflammation

• Main Authors: Yanke Chen (Author), Li Zhang (Author), Jingshu Ni (Author), Xiaoyu Wang (Author), Jian Cheng (Author), Yuanchao Li (Author), Xuechu Zhen (Author), Ting Cao (Author), Jia Jia (Author)
• Format: Book
• Published: Elsevier, 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: (5R)-5-Hydroxytriptolide (LLDT-8), an analogue of triptolide, displays lower toxicity compared to triptolide and has comparable immunosuppressive effects. We investigated the anti-inflammatory and neuroprotective effects of LLDT-8 on cerebral ischemia/reperfusion injury. Methods: Nitric oxide p...