The Role of Voltage-Gated Sodium Channel 1.8 in the Effect of Atropine on Heart Rate: Evidence From a Retrospective Clinical Study and Mouse Model

• Main Authors: Baowen Liu (Author), Ningbo Li (Author), Jin Zhang (Author), Yi Liu (Author), Mi Zhang (Author), Yishun Hong (Author), Wenyao Wu (Author), Xianwei Zhang (Author), Guangyou Duan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Atropine is commonly used to counter the effects of the parasympathetic neurotransmitter acetylcholine on heart rate in clinical practice, such as in the perioperative period; however, individual differences in the response to atropine are huge. The association between SCN10A/voltage-gated sodium ch...