Low mitochondrial DNA copy number in peripheral blood mononuclear cells is associated with future mortality risk: a long-term follow-up study from Japan

• Main Authors: Genki Mizuno (Author), Hiroya Yamada (Author), Yoshiki Tsuboi (Author), Eiji Munetsuna (Author), Mirai Yamazaki (Author), Yoshitaka Ando (Author), Itsuki Kageyama (Author), Yuki Nouchi (Author), Atsushi Teshigawara (Author), Yuji Hattori (Author), Ryosuke Fujii (Author), Hiroaki Ishikawa (Author), Shuji Hashimoto (Author), Koji Ohashi (Author), Nobuyuki Hamajima (Author), Koji Suzuki (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: The mitochondrial DNA (mtDNA) is unique and circular with multiple copies of the genome. The lower mtDNA copy number (mtDNA-CN) in leukocytes is associated with the risk of all-cause mortality. However, its long-term association is unknown. Thus, the study examined the association betwee...