Dual Targeting Ligands-Histamine H₃ Receptor Ligands with Monoamine Oxidase B Inhibitory Activity-In Vitro and In Vivo Evaluation

• Main Authors: Dorota Łażewska (Author), Agata Siwek (Author), Agnieszka Olejarz-Maciej (Author), Agata Doroz-Płonka (Author), Anna Wiktorowska-Owczarek (Author), Marta Jóźwiak-Bębenista (Author), David Reiner-Link (Author), Annika Frank (Author), Wioletta Sromek-Trzaskowska (Author), Ewelina Honkisz-Orzechowska (Author), Ewelina Królicka (Author), Holger Stark (Author), Marek Wieczorek (Author), Waldemar Wagner (Author), Katarzyna Kieć-Kononowicz (Author), Anna Stasiak (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical symptoms of Parkinson's disease (PD) appear when dopamine (DA) concentrations in the striatum drops to around 20%. Simultaneous inhibitory effects on histamine H₃ receptor (H₃R) and MAO B can increase DA levels in the brain. A series of...