Effects of Bifemelane on the Calcium Level and ATP Release of the Human Origin Astrocyte Clonal Cell

• Main Authors: Yoshitoku Yoshida (Author), Haruno Kumagai (Author), Yoshiumi Ohkubo (Author), Remi Tsuchiya (Author), Mitsuhiro Morita (Author), Hiroyoshi Miyakawa (Author), Yoshihisa Kudo (Author)
• Format: Book
• Published: Elsevier, 2006-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effect of bifemelane hydrochloride (bifemelane) was examined on human origin astrocyte clonal cells (Kings-1). Bifemelane (125 - 1000 µM) induced a dose-dependent increase in the intracellular calcium concentration ([Ca2+]i). In the highest concentration (1000 µM), the drug caused the second lar...