The Design, Synthesis, and Evaluation of Diaminopimelic Acid Derivatives as Potential <i>dap</i>F Inhibitors Preventing Lysine Biosynthesis for Antibacterial Activity

• Main Authors: Mohd Sayeed Shaikh (Author), Mayura A. Kale (Author), V. Muralidharan (Author), T. Venkatachalam (Author), Syed Sarfaraz Ali (Author), Fahadul Islam (Author), Sharuk L. Khan (Author), Falak A. Siddiqui (Author), Humaira Urmee (Author), Ganesh G. Tapadiya (Author), Sachin A. Dhawale (Author), Long Chiau Ming (Author), Ibrahim Abdel Aziz Ibrahim (Author), Abdullah R. Alzahrani (Author), Md. Moklesur Rahman Sarker (Author), Mohd Fahami Nur Azlina (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We created thiazole and oxazole analogues of diaminopimelic acid (DAP) by replacing its carboxyl groups and substituting sulphur for the central carbon atom. Toxicity, ADME, molecular docking, and in vitro antimicrobial studies of the synthesized compounds were carried out. These compounds displayed...