Bilirubin Improves Gap Junction to Alleviate Doxorubicin-Induced Cardiotoxicity by Regulating AMPK-Axl-SOCS3-Cx43 Axis

• Main Authors: Siqi Zhang (Author), Yixin Fan (Author), Binbin Zheng (Author), Yu Wang (Author), Chen Miao (Author), Yue Su (Author), Kun Li (Author), Yan E. (Author), Xueli Wang (Author), Xueming He (Author), Xuefeng Wu (Author), Chenjie Xu (Author), Yulin Tang (Author), Wen-Tao Liu (Author), Xiangqing Kong (Author), Liang Hu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Doxorubicin induces severe cardiotoxicity, accompanied by the high level of bilirubin in the blood. The conventional wisdom is that bilirubin is considered as a marker of liver damage. By contrast, here we aim to explore the potential protective effect of bilirubin on doxorubicin-induced cardiotoxic...