Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics

• Ngā kaituhi matua: Melissa L. Geddie (Author), Dmitri B. Kirpotin (Author), Neeraj Kohli (Author), Tad Kornaga (Author), Bjoern Boll (Author), Maja Razlog (Author), Daryl C. Drummond (Author), Alexey A. Lugovskoy (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Antibody-directed nanotherapeutics (ADNs) represent a promising delivery platform for selective delivery of an encapsulated drug payload to the site of disease that improves the therapeutic index. Although both single-chain Fv (scFv) and Fab antibody fragments have been used for targeting, no platfo...