Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics

• 主要な著者: Melissa L. Geddie (著者), Dmitri B. Kirpotin (著者), Neeraj Kohli (著者), Tad Kornaga (著者), Bjoern Boll (著者), Maja Razlog (著者), Daryl C. Drummond (著者), Alexey A. Lugovskoy (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Antibody-directed nanotherapeutics (ADNs) represent a promising delivery platform for selective delivery of an encapsulated drug payload to the site of disease that improves the therapeutic index. Although both single-chain Fv (scFv) and Fab antibody fragments have been used for targeting, no platfo...