Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P

• Main Authors: Darya Novopashina (Author), Mariya Vorobyeva (Author), Anton Nazarov (Author), Anna Davydova (Author), Nikolay Danilin (Author), Lyudmila Koroleva (Author), Andrey Matveev (Author), Alevtina Bardasheva (Author), Nina Tikunova (Author), Maxim Kupryushkin (Author), Dmitrii Pyshnyi (Author), Sidney Altman (Author), Alya Venyaminova (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2'-O-methyl RNA (2'-OMe-RNA...