Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages

• Main Authors: Daniel Vašek (Author), Natálie Fikarová (Author), Vendula Nagy Marková (Author), Ondřej Honc (Author), Lenka Pacáková (Author), Bianka Porubská (Author), Veronika Somova (Author), Jiří Novotný (Author), Barbora Melkes (Author), Magdaléna Krulová (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The transient receptor potential vanilloid 1 (TRPV1) is well-established in neuronal function, yet its role in immune reactions remains enigmatic. The conflicting data on its inflammatory role, suggesting both pro-inflammatory and anti-inflammatory effects upon TRPV1 stimulation...