Design, synthesis, biological evaluation and molecular docking study of novel pleuromutilin derivatives containing substituted benzoxazole as antibacterial agents

• Автори: Jie Ren (Автор), Qi-Wen Zhang (Автор), Xian-Jin He (Автор), Xiao-Ying Chen (Автор), Zi-Dan Zhou (Автор), Zhen-Ling Zeng (Автор), Zhen Jin (Автор), You-Zhi Tang (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

A series of pleuromutilin analogs containing substituted benzoxazole were designed, synthesised, and assessed for their antibacterial activity both in vivo and in vitro. The MIC of the synthesised derivatives was initially assessed using the broth dilution method against four strains of Staphylococc...