Design, synthesis, biological evaluation and molecular docking study of novel pleuromutilin derivatives containing substituted benzoxazole as antibacterial agents

• Main Authors: Jie Ren (Author), Qi-Wen Zhang (Author), Xian-Jin He (Author), Xiao-Ying Chen (Author), Zi-Dan Zhou (Author), Zhen-Ling Zeng (Author), Zhen Jin (Author), You-Zhi Tang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of pleuromutilin analogs containing substituted benzoxazole were designed, synthesised, and assessed for their antibacterial activity both in vivo and in vitro. The MIC of the synthesised derivatives was initially assessed using the broth dilution method against four strains of Staphylococc...