MTORC1 inhibition drives crinophagic degradation of glucagon

• Main Authors: Sangam Rajak (Author), Sherwin Xie (Author), Archana Tewari (Author), Sana Raza (Author), Yajun Wu (Author), Boon-Huat Bay (Author), Paul M. Yen (Author), Rohit A. Sinha (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Crinophagy is a secretory granule-specific autophagic process that regulates hormone content and secretion in endocrine cells. However, despite being one of the earliest described autophagic processes, its mechanism of action and regulation in mammalian cells remains unclear. Methods and...