Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk

• Main Authors: Jiao Wu (Author), Jiangling Dong (Author), Daniela Verzola (Author), Keith Hruska (Author), Giacomo Garibotto (Author), Zhaoyong Hu (Author), William E. Mitch (Author), Sandhya S. Thomas (Author)
• Format: Book
• Published: Wiley, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα), which leads to cachexia in mice and is...