Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk

Abstract Background Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα), which leads to cachexia in mice and is...

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Main Authors: Jiao Wu (Author), Jiangling Dong (Author), Daniela Verzola (Author), Keith Hruska (Author), Giacomo Garibotto (Author), Zhaoyong Hu (Author), William E. Mitch (Author), Sandhya S. Thomas (Author)
Format: Book
Published: Wiley, 2019-12-01T00:00:00Z.
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