Leishmania donovani argininosuccinate synthase is an active enzyme associated with parasite pathogenesis.

• Main Authors: Ines Lakhal-Naouar (Author), Armando Jardim (Author), Rona Strasser (Author), Shen Luo (Author), Yukiko Kozakai (Author), Hira L Nakhasi (Author), Robert C Duncan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Gene expression analysis in Leishmania donovani (Ld) identified an orthologue of the urea cycle enzyme, argininosuccinate synthase (LdASS), that was more abundantly expressed in amastigotes than in promastigotes. In order to characterize in detail this newly identified protein in Leishma...