Inhibition of integrin alpha v/beta 5 mitigates the protective effect induced by irisin in hemorrhage

• Main Authors: Lijiang Wang (Author), Supaporn Kulthinee (Author), John Slate-Romano (Author), Thomas Zhao (Author), Hamsa Shanmugam (Author), Patrycja M Dubielecka (Author), Ling X. Zhang (Author), Gangjian Qin (Author), Shougang Zhuang (Author), Y. Eugene Chin (Author), Ting C. Zhao (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Irisin plays an important role in regulating tissue stress, cardiac function, and inflammation. Integrin αvβ5 was recently identified as a receptor for irisin to elicit its physiologic function. It remains unknown whether integrin αvβ5 is required for irisin's function in modulati...