PD-L1 dimerisation induced by biphenyl derivatives mediates anti-breast cancer activity via the non-immune PD-L1-AKT-mTOR/Bcl2 pathway

• Главные авторы: Hua Zhang (Автор), Shi-Jia Zhou (Автор), Chen-Feng Shen (Автор), Yong-Nan Zhou (Автор), Cai-Yun Wu (Автор), Meng-Yu Zhu (Автор), Qi-Meng Yu (Автор), Annoor Awadasseid (Автор), Yan-Ling Wu (Автор), Wen Zhang (Автор)
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• Опубликовано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предметы: article
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Recent studies on biphenyl-containing compounds, a type of PD-1/PD-L1 blocker which binds to PD-L1 and induces dimerisation, have focussed on its immune function. Herein, 10 novel biphenyl derivatives were designed and synthesised. The results of the CCK-8 showed that compounds have different anti-t...