PD-L1 dimerisation induced by biphenyl derivatives mediates anti-breast cancer activity via the non-immune PD-L1-AKT-mTOR/Bcl2 pathway

• Glavni autori: Hua Zhang (Autor), Shi-Jia Zhou (Autor), Chen-Feng Shen (Autor), Yong-Nan Zhou (Autor), Cai-Yun Wu (Autor), Meng-Yu Zhu (Autor), Qi-Meng Yu (Autor), Annoor Awadasseid (Autor), Yan-Ling Wu (Autor), Wen Zhang (Autor)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Recent studies on biphenyl-containing compounds, a type of PD-1/PD-L1 blocker which binds to PD-L1 and induces dimerisation, have focussed on its immune function. Herein, 10 novel biphenyl derivatives were designed and synthesised. The results of the CCK-8 showed that compounds have different anti-t...