PD-L1 dimerisation induced by biphenyl derivatives mediates anti-breast cancer activity via the non-immune PD-L1-AKT-mTOR/Bcl2 pathway

• Main Authors: Hua Zhang (Author), Shi-Jia Zhou (Author), Chen-Feng Shen (Author), Yong-Nan Zhou (Author), Cai-Yun Wu (Author), Meng-Yu Zhu (Author), Qi-Meng Yu (Author), Annoor Awadasseid (Author), Yan-Ling Wu (Author), Wen Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies on biphenyl-containing compounds, a type of PD-1/PD-L1 blocker which binds to PD-L1 and induces dimerisation, have focussed on its immune function. Herein, 10 novel biphenyl derivatives were designed and synthesised. The results of the CCK-8 showed that compounds have different anti-t...