Notch-1 Confers Chemoresistance in Lung Adenocarcinoma to Taxanes through AP-1/microRNA-451 Mediated Regulation of MDR-1

• Main Authors: Jiayuan Huang (Author), Yitian Chen (Author), Junyang Li (Author), Kai Zhang (Author), Jing Chen (Author), Dongqin Chen (Author), Bing Feng (Author), Haizhu Song (Author), Jifeng Feng (Author), Rui Wang (Author), Longbang Chen (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously demonstrated that expression of Notch-1 is associated with poor prognosis in lung adenocarcinoma (LAD) patients. The aim of this study is to reveal whether Notch-1 was associated with Taxanes-resistant LAD and, the underlying mechanisms. We collected 39 patients of advanced LAD treated...