3'-Methyl-4-thio-1H-tetrahydropyranspiro-5'-hydantoin platinum complex as a novel deoxyribonuclease I inhibitor

• Main Authors: Ana Marković (Author), Mariyana Atanasova (Author), Rossen Buyukliev (Author), Adriana Bakalova (Author), Andrija Šmelcerović (Author), Emiliya Cherneva (Author)
• Format: Book
• Published: Pensoft Publishers, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Deoxyribonuclease I (DNase I) is one of the main nucleases involved in deoxyribonucleic acid (DNA) degradation during apoptosis. It catalyzes the hydrolytic cleavage of DNA, producing 5'-oligonucleotides. The inhibition of DNase I may serve as an important mechanism for protecting DNA against p...