Synthesis and anti-hepatocellular carcinoma activity of aminopyridinol-sorafenib hybrids

• Main Authors: Bhuwan Prasad Awasthi (Author), Prakash Chaudhary (Author), Diwakar Guragain (Author), Jun-Goo Jee (Author), Jung-Ae Kim (Author), Byeong-Seon Jeong (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sorafenib is recommended as the primary therapeutic drug for patients with hepatocellular carcinoma. To discover a new compound that avoids low response rates and toxic side effects that occur in sorafenib therapy, we designed and synthesized new hybrid compounds of sorafenib and 2,4,5-trimethylpyri...