A Dynamic Mass Redistribution Assay for the Human Sweet Taste Receptor Uncovers G-Protein Dependent Biased Ligands

• Main Authors: Nicole B. Servant (Author), Mark E. Williams (Author), Paul F. Brust (Author), Huixian Tang (Author), Melissa S. Wong (Author), Qing Chen (Author), Marketa Lebl-Rinnova (Author), Sara L. Adamski-Werner (Author), Catherine Tachdjian (Author), Guy Servant (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The sweet taste receptor is rather unique, recognizing a diverse repertoire of natural or synthetic ligands, with a surprisingly large structural diversity, and with potencies stretching over more than six orders of magnitude. Yet, it is not clear if different cell-based assays can faithfully report...