FeTPPS, a Peroxynitrite Decomposition Catalyst, Ameliorates Nitrosative Stress in Human Spermatozoa

• Main Authors: Pamela Uribe (Author), Javiera Barra (Author), Kevin Painen (Author), Fabiola Zambrano (Author), Mabel Schulz (Author), Claudia Moya (Author), Vladimir Isachenko (Author), Evgenia Isachenko (Author), Peter Mallmann (Author), Raúl Sánchez (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive levels of reactive nitrogen species (RNS), such as peroxynitrite, promote nitrosative stress, which is an important cause of impaired sperm function. The metalloporphyrin FeTPPS is highly effective in catalyzing the decomposition of peroxynitrite, reducing its toxic effects in vivo and in...