Cynomolgus macaques naturally infected with Trypanosoma cruzi-I exhibit an overall mixed pro-inflammatory/modulated cytokine signature characteristic of human Chagas disease.

• Main Authors: Danielle Marquete Vitelli-Avelar (Author), Renato Sathler-Avelar (Author), Armanda Moreira Mattoso-Barbosa (Author), Nicolas Gouin (Author), Marcelo Perdigão- (Author), Leydiane Valério- (Author), Ronaldo Peres Costa (Author), Silvana Maria Elói-Santos (Author), Matheus de Souza Gomes (Author), Laurence Rodrigues do Amaral (Author), Andréa Teixeira-Carvalho (Author), Olindo Assis Martins-Filho (Author), Edward J Dick (Author), Gene B Hubbard (Author), Jane F VandeBerg (Author), John L VandeBerg (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Non-human primates have been shown to be useful models for Chagas disease. We previously reported that natural T. cruzi infection of cynomolgus macaques triggers clinical features and immunophenotypic changes of peripheral blood leukocytes resembling those observed in human Chagas disease...