High expression of interleukine-1 receptor antagonist in rheumatoid arthritis: Association with IL1RN*2/2 genotype

• Main Authors: S. Ramírez-Pérez (Author), U. De la Cruz-Mosso (Author), J. Hernández-Bello (Author), G. E. Martínez-Bonilla (Author), M. G. Ramírez-Dueñas (Author), A. L. Pereira-Suárez (Author), I. Parra Rojas (Author), E. Martínez-López (Author), J. Macías-Barragán (Author), J. F. Muñoz-Valle (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation and pro-inflammatory cytokines production. IL-1Ra is an anti-inflammatory cytokine codified by IL1RN gene that blocks IL-1 signalling. A VNTR polymorphism of 86 bp in IL1RN gene has been associated with RA risk and regu...